Issue 71, 2014
From the journal:

Chemical Communications

A chemical switch for controlling viral infectivity†

Maximilian Hörner,‡abc   Beate Kaufmann,‡a   Gabriella Cotugno,d   Ellen Wiedtke,d   Hildegard Büning,‡e   Dirk Grimm‡d  and  Wilfried Weber*abc  

* Corresponding authors

a Faculty of Biology, University of Freiburg, Schänzlestrasse 1, 79104 Freiburg, Germany
E-mail: wilfried.weber@biologie.uni-freiburg.de
Fax: +49 761 203 97660
Tel: +49 761 203 97654

b BIOSS – Centre for Biological Signalling Studies, University of Freiburg, Schänzlestrasse 18, 79104 Freiburg, Germany

c SGBM – Spemann Graduate School of Biology and Medicine, University of Freiburg, Albertstrasse 19A, 79104 Freiburg, Germany

d Heidelberg University, Cluster of Excellence CellNetworks, Department of Infectious Diseases, Virology, Im Neuenheimer Feld 267, 69120 Heidelberg, Germany

e Center for Molecular Medicine Cologne (CMMC), University of Cologne, CMMC Research Building, Robert-Koch-Str. 21, 50931 Cologne, Germany

Abstract

Chemically triggered molecular switches for controlling the fate and function of biological systems are fundamental to the emergence of synthetic biology and the development of biomedical applications. We here present the first chemically triggered switch for controlling the infectivity of adeno-associated viral (AAV) vectors.

Graphical abstract: A chemical switch for controlling viral infectivity

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Article information

DOI
https://doi.org/10.1039/C4CC03292F
Article type
Communication
Submitted
02 May 2014
Accepted
26 Jun 2014
First published
17 Jul 2014
This article is Open Access
Creative Commons BY license

Chem. Commun., 2014,50, 10319-10322

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A chemical switch for controlling viral infectivity

M. Hörner, B. Kaufmann, G. Cotugno, E. Wiedtke, H. Büning, D. Grimm and W. Weber, Chem. Commun., 2014, 50, 10319 DOI: 10.1039/C4CC03292F

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