Issue 58, 2014
From the journal:

Chemical Communications

Dual pH-triggered multistage drug delivery systems based on host–guest interaction-associated polymeric nanogels†

Minghui Zan,ab   Junjie Li,a   Shizhong Luo*b  and  Zhishen Ge*a  

* Corresponding authors

a CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, China
E-mail: gezs@ustc.edu.cn

b Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Key Laboratory of Molecule-based Materials, College of Chemistry and Materials Science, Anhui Normal University, Wuhu, Anhui, China
E-mail: shzhluo@mail.ahnu.edu.cn

Abstract

The polymeric nanogels were constructed via host–guest interactions for dual pH-triggered multistage drug delivery, which showed tumor acidity-triggered nanogel reorganization into smaller nanoparticles for deep tissue penetration, high-efficiency cellular uptake, and intracellular endo-lysosomal pH-responsive drug release.

Graphical abstract: Dual pH-triggered multistage drug delivery systems based on host–guest interaction-associated polymeric nanogels

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Article information

DOI
https://doi.org/10.1039/C4CC03120B
Article type
Communication
Submitted
19 Apr 2014
Accepted
27 May 2014
First published
02 Jun 2014

Chem. Commun., 2014,50, 7824-7827

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Dual pH-triggered multistage drug delivery systems based on host–guest interaction-associated polymeric nanogels

M. Zan, J. Li, S. Luo and Z. Ge, Chem. Commun., 2014, 50, 7824 DOI: 10.1039/C4CC03120B

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