Issue 63, 2014
From the journal:

Chemical Communications

Selection of aptamers targeting the sialic acid receptor of hemagglutinin by epitope-specific SELEX†

Yeh-Hsing Lao,ab   Hui-Yu Chiang,a   Deng-Kai Yang,a   Konan Peckb  and  Lin-Chi Chen*a  

* Corresponding authors

a Department of Bio-Industrial Mechatronics Engineering, National Taiwan University, Taipei 10617, Taiwan
E-mail: chenlinchi@ntu.edu.tw

b Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan

Abstract

A new SELEX scheme is proposed for the selection of aptamers targeting a specific epitope of a native protein. Anti-sialic acid receptor (SAR) aptamers that inhibit H1 hemagglutination at a low picomole dose are selected accordingly.

Graphical abstract: Selection of aptamers targeting the sialic acid receptor of hemagglutinin by epitope-specific SELEX

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Article information

DOI
https://doi.org/10.1039/C4CC03116D
Article type
Communication
Submitted
27 Apr 2014
Accepted
18 May 2014
First published
19 May 2014

Chem. Commun., 2014,50, 8719-8722

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Selection of aptamers targeting the sialic acid receptor of hemagglutinin by epitope-specific SELEX

Y. Lao, H. Chiang, D. Yang, K. Peck and L. Chen, Chem. Commun., 2014, 50, 8719 DOI: 10.1039/C4CC03116D

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