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Issue 55, 2014
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Designed cell penetrating peptide dendrimers efficiently internalize cargo into cells

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Abstract

Redesigning linear cell penetrating peptides (CPPs) into a multi-branched topology with short dipeptide branches gave cell penetrating peptide dendrimers (CPPDs) with higher cell penetration, lower toxicity and hemolysis and higher serum stability than linear CPPs. Their use is demonstrated by delivering a cytotoxic peptide and paclitaxel into cells.

Graphical abstract: Designed cell penetrating peptide dendrimers efficiently internalize cargo into cells

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Supplementary files

Article information


Submitted
15 Apr 2014
Accepted
15 May 2014
First published
15 May 2014

This article is Open Access

Chem. Commun., 2014,50, 7254-7257
Article type
Communication
Author version available

Designed cell penetrating peptide dendrimers efficiently internalize cargo into cells

G. A. Eggimann, E. Blattes, S. Buschor, R. Biswas, S. M. Kammer, T. Darbre and J. Reymond, Chem. Commun., 2014, 50, 7254
DOI: 10.1039/C4CC02780A

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    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
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    [Original citation] - Published by the PCCP Owner Societies.
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    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
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    [Original citation] - Published by The Royal Society of Chemistry.

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