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Issue 61, 2014
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Biomass derived furfural-based facile synthesis of protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs

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Abstract

An efficient synthetic route towards tosyl-protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs, has been developed in 5 steps in 54% yield from biomass derived furfural. The synthetic utility of the piperidone core structure was demonstrated with the synthesis of a NK1 receptor antagonist.

Graphical abstract: Biomass derived furfural-based facile synthesis of protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs

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Publication details

The article was received on 10 Apr 2014, accepted on 01 May 2014 and first published on 01 May 2014


Article type: Communication
DOI: 10.1039/C4CC02645D
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Chem. Commun., 2014,50, 8324-8327
  • Open access: Creative Commons BY-NC license
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    Biomass derived furfural-based facile synthesis of protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs

    P.-F. Koh, P. Wang, J.-M. Huang and T.-P. Loh, Chem. Commun., 2014, 50, 8324
    DOI: 10.1039/C4CC02645D

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