Issue 57, 2014
From the journal:

Chemical Communications

Carbon nanoparticle-protected aptamers for highly sensitive and selective detection of biomolecules based on nuclease-assisted target recycling signal amplification†

Xiaoyan Lin,a   Liang Cui,a   Yishun Huang,a   Ya Lin,a   Yi Xie,a   Zhi Zhu,*a   Bincheng Yin,b   Xi Chena  and  Chaoyong James Yang*a  

* Corresponding authors

a The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, The Key Laboratory of Chemical Biology of Fujian Province, State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China
E-mail: zhuzhi@xmu.edu.cn, cyyang@xmu.edu.cn

b State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China

Abstract

Based on the protective properties of carbon nanoparticles for aptamers against the digestion of nuclease, we have developed a nuclease-assisted target recycling signal amplification method for highly sensitive detection of biomolecules, such as ATP and kanamycin. The high binding specificity between aptamers and targets leads to excellent selectivity of the assay.

Graphical abstract: Carbon nanoparticle-protected aptamers for highly sensitive and selective detection of biomolecules based on nuclease-assisted target recycling signal amplification

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Article information

DOI
https://doi.org/10.1039/C4CC02184C
Article type
Communication
Submitted
25 Mar 2014
Accepted
22 May 2014
First published
22 May 2014

Chem. Commun., 2014,50, 7646-7648

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Carbon nanoparticle-protected aptamers for highly sensitive and selective detection of biomolecules based on nuclease-assisted target recycling signal amplification

X. Lin, L. Cui, Y. Huang, Y. Lin, Y. Xie, Z. Zhu, B. Yin, X. Chen and C. J. Yang, Chem. Commun., 2014, 50, 7646 DOI: 10.1039/C4CC02184C

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