Issue 69, 2014
From the journal:

Chemical Communications

A novel fully water-soluble Cu(i) probe for fluorescence live cell imaging†

Maria Laura Giuffrida,a   Enrico Rizzarelli,a   Gaetano A. Tomaselli,b   Cristina Satriano*b  and  Giuseppe Trusso Sfrazzetto*b  

* Corresponding authors

a Institute of Biostructure and Bioimaging, National Research Council, Viale Andrea Doria, Catania 95125, Italy

b Department of Chemical Sciences, University of Catania, Viale Andrea Doria, 6, 95125 Catania, Italy
E-mail: csatrian@unict.it, giuseppe.trusso@unict.it
Fax: +39 095 337678
Tel: +39 095 7385148

Abstract

A new Cu(I) probe (OBEP-CS1), bearing an alkyl-pyridinium moiety to get complete water solubility, was synthesized. Fluorescence titrations support copper binding and high selectivity in a water solution whereas formation of aggregates was excluded by DOSY experiments. The detection capability for intracellular Cu(I), especially localized in mitochondria, was demonstrated in differentiated neuroblastoma cells by confocal microscopy.

Graphical abstract: A novel fully water-soluble Cu(i) probe for fluorescence live cell imaging

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Article information

DOI
https://doi.org/10.1039/C4CC02147A
Article type
Communication
Submitted
23 Mar 2014
Accepted
06 May 2014
First published
06 May 2014

Chem. Commun., 2014,50, 9835-9838

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A novel fully water-soluble Cu(I) probe for fluorescence live cell imaging

M. L. Giuffrida, E. Rizzarelli, G. A. Tomaselli, C. Satriano and G. Trusso Sfrazzetto, Chem. Commun., 2014, 50, 9835 DOI: 10.1039/C4CC02147A

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