Site-specific cross-linking of collagen peptides by lysyl advanced glycation endproducts†
Cross-linking of proteins by advanced glycation endproducts (AGEs) causes a host of pathological conditions but their exact roles are unknown. Cross-linking lysyl AGEs were synthesized and incorporated into two types of collagen peptides. The utility of these cross-linked peptides for biochemical investigations was demonstrated by proteolysis studies and circular dichroism.
- This article is part of the themed collection: In Celebration of Richard Taylor’s 65th Birthday