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Issue 62, 2014
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Catalytic carbene transfer allows the direct customization of cyclic purine dinucleotides

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Abstract

We describe a simple method for the direct modification of nucleobases in cyclic purine dinucleotides, important signalling molecules in both prokaryotes and eukaryotes. The method tolerates all members of the cyclic dinucleotide family and could be used to modulate their function or introduce useful side-chains such as fluorophores and photo-crosslinking groups.

Graphical abstract: Catalytic carbene transfer allows the direct customization of cyclic purine dinucleotides

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Publication details

The article was received on 14 Mar 2014, accepted on 24 May 2014 and first published on 20 Jun 2014


Article type: Communication
DOI: 10.1039/C4CC01919A
Citation: Chem. Commun., 2014,50, 8499-8502
  • Open access: Creative Commons BY license
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    Catalytic carbene transfer allows the direct customization of cyclic purine dinucleotides

    N. Fei, D. Häussinger, S. Blümli, B. Laventie, L. D. Bizzini, K. Zimmermann, U. Jenal and D. Gillingham, Chem. Commun., 2014, 50, 8499
    DOI: 10.1039/C4CC01919A

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