Issue 51, 2014
From the journal:

Chemical Communications

A simple access to N-(un)substituted isoquinolin-1(2H)-ones: unusual formation of regioisomeric isoquinolin-1(4H)-ones†

R. Gangadhara Chary,ab   G. Dhananjaya,a   K. Vara Prasad,a   S. Vaishaly,a   Y. S. S. Ganesh,a   Balakrishna Dulla,c   K. Shiva Kumarc  and  Manojit Pal*c  

* Corresponding authors

a Custom Pharmaceutical Services, Dr Reddy's Laboratories Limited, Bollaram Road Miyapur, Hyderabad 500 049, India

b Chemistry Division, JNT University, Kukatpally, Hyderabad 500085, Andhra Pradesh, India

c Dr Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India
E-mail: manojitpal@rediffmail.com
Tel: +91 40 6657 1500

Abstract

A ligand/additive/Pd-free Cu-mediated coupling/cyclization strategy afforded the first practical, one-pot and general approach towards synthesis of N-(un)substituted isoquinolin-1(2H)-ones. Both the catalyst and the solvent used are recyclable. The use of the Cu reagent in excess led to the unusual formation of regioisomeric and uncommon isoquinolin-1(4H)-ones.

Graphical abstract: A simple access to N-(un)substituted isoquinolin-1(2H)-ones: unusual formation of regioisomeric isoquinolin-1(4H)-ones

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Article information

DOI
https://doi.org/10.1039/C4CC01580K
Article type
Communication
Submitted
02 Mar 2014
Accepted
06 May 2014
First published
06 May 2014

Chem. Commun., 2014,50, 6797-6800

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A simple access to N-(un)substituted isoquinolin-1(2H)-ones: unusual formation of regioisomeric isoquinolin-1(4H)-ones

R. G. Chary, G. Dhananjaya, K. V. Prasad, S. Vaishaly, Y. S. S. Ganesh, B. Dulla, K. S. Kumar and M. Pal, Chem. Commun., 2014, 50, 6797 DOI: 10.1039/C4CC01580K

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