Issue 46, 2014

Synthesis and evaluation of turn-on fluorescent probes for imaging steroid sulfatase activities in cells

Abstract

We have synthesized and evaluated two self-immobilizing, turn-on fluorescent probes carrying a coumarin molecular framework for imaging intracellular human steroid sulfatase (STS) activity. The 8-fluoromethyl coumarin derivative, which gives stronger fluorescence response in the incubation study with STS preparations, was successfully applied to visualize STS activity in cells.

Graphical abstract: Synthesis and evaluation of turn-on fluorescent probes for imaging steroid sulfatase activities in cells

Supplementary files

Article information

Article type
Communication
Submitted
18 Feb 2014
Accepted
16 Apr 2014
First published
16 Apr 2014

Chem. Commun., 2014,50, 6116-6119

Author version available

Synthesis and evaluation of turn-on fluorescent probes for imaging steroid sulfatase activities in cells

C. Tai, C. Lu, S. Wu and L. Lo, Chem. Commun., 2014, 50, 6116 DOI: 10.1039/C4CC01282H

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