We performed the reaction of vitamin B12 with N,N-dimethylformamide dimethyl acetal for primary amide activation, and added MeOH as a nucleophile, to afford cobalester, the first amphiphilic cobalamin derivative. The unique combination of redox properties and solubility represents an asset for its use as a catalyst in C–C bond forming reactions.
M. Giedyk, S. N. Fedosov and D. Gryko, Chem. Commun., 2014, 50, 4674 DOI: 10.1039/C4CC01064G
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