Issue 31, 2014

Stereospecific conversion of alcohols into pinacol boronic esters using lithiation–borylation methodology with pinacolborane

Abstract

The synthesis of primary and secondary pinacol boronic esters via lithiation–borylation of carbamates and benzoates with pinacolborane is described. This new protocol enables the highly selective synthesis of enantioenriched and geometrically defined boronic esters that cannot otherwise be accessed by alternative methodologies.

Graphical abstract: Stereospecific conversion of alcohols into pinacol boronic esters using lithiation–borylation methodology with pinacolborane

Supplementary files

Article information

Article type
Communication
Submitted
06 Feb 2014
Accepted
26 Feb 2014
First published
26 Feb 2014
This article is Open Access
Creative Commons BY license

Chem. Commun., 2014,50, 4053-4055

Author version available

Stereospecific conversion of alcohols into pinacol boronic esters using lithiation–borylation methodology with pinacolborane

S. Roesner, C. A. Brown, M. Mohiti, A. P. Pulis, R. Rasappan, D. J. Blair, S. Essafi, D. Leonori and V. K. Aggarwal, Chem. Commun., 2014, 50, 4053 DOI: 10.1039/C4CC00993B

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