Issue 66, 2014
From the journal:

Chemical Communications

Impact of molecular charge on GLUT-specific cellular uptake of glucose bioprobes and in vivo application of the glucose bioprobe, GB2-Cy3†

Jongmin Park,a   Jung In Um,b   Ala Jo,a   Jinho Lee,b   Da-Woon Jung,b   Darren R. Williams*b  and  Seung Bum Park*ac  

* Corresponding authors

a Department of Chemistry, Seoul National University, Seoul 151-747, Korea
E-mail: sbpark@snu.ac.kr

b School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500-712, Korea
E-mail: darren@gist.ac.kr

c Department of Biophysics and Chemical Biology, Institutes of Entrepreneurial BioConvergence, Seoul National University, Seoul 151-747, Korea

Abstract

The molecular charge of fluorescent bioprobes has recently received much attention due to its influence on cellular uptake. Herein, we demonstrate the effect of the molecular charge of glucose bioprobes on their GLUT-specific cellular uptake. We also applied GB2-Cy3 to in vivo imaging in the zebrafish model.

Graphical abstract: Impact of molecular charge on GLUT-specific cellular uptake of glucose bioprobes and in vivo application of the glucose bioprobe, GB2-Cy3

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Article information

DOI
https://doi.org/10.1039/C4CC00955J
Article type
Communication
Submitted
05 Feb 2014
Accepted
04 Apr 2014
First published
09 Apr 2014

Chem. Commun., 2014,50, 9251-9254

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Impact of molecular charge on GLUT-specific cellular uptake of glucose bioprobes and in vivo application of the glucose bioprobe, GB2-Cy3

J. Park, J. I. Um, A. Jo, J. Lee, D. Jung, D. R. Williams and S. B. Park, Chem. Commun., 2014, 50, 9251 DOI: 10.1039/C4CC00955J

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