Issue 42, 2014
From the journal:

Chemical Communications

Programmable drug release using bioresponsive mesoporous silica nanoparticles for site-specific oral drug delivery†

Amirali Popat,abc   Siddharth Jambhrunkar,a   Jun Zhang,a   Jie Yang,a   Honwei Zhang,a   Anand Mekaa  and  Chengzhong Yu*a  

* Corresponding authors

a Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Australia
E-mail: c.yu@uq.edu.au
Fax: +61 7 3346 3973
Tel: +61 7 3346 3283

b The School of Pharmacy, The University of Queensland, Brisbane, Australia

c Mucosal Diseases Group, Mater Research Institute – The University of Queensland, Translational Research Institute, 37 Kent St, Woolloongabba, Australia

Abstract

Novel mesoporous silica nanoparticles (MSNs) responsive to multiple biological stimuli (pH and enzymes) were prepared through conjugation with a structure modified soy protein isolate. The particles show an extremely high pro-drug (sulfasalazine) loading with programmable drug release in simulated gastrointestinal fluid.

Graphical abstract: Programmable drug release using bioresponsive mesoporous silica nanoparticles for site-specific oral drug delivery

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Article information

DOI
https://doi.org/10.1039/C4CC00620H
Article type
Communication
Submitted
24 Jan 2014
Accepted
17 Feb 2014
First published
17 Feb 2014

Chem. Commun., 2014,50, 5547-5550

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Programmable drug release using bioresponsive mesoporous silica nanoparticles for site-specific oral drug delivery

A. Popat, S. Jambhrunkar, J. Zhang, J. Yang, H. Zhang, A. Meka and C. Yu, Chem. Commun., 2014, 50, 5547 DOI: 10.1039/C4CC00620H

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