Functionalization of an sp3 C–H bond via a redox-neutral domino reaction: diastereoselective synthesis of hexahydropyrrolo[2,1-b]oxazoles†
Abstract
A diastereoselective synthesis of pyrrolidinooxazolidines was achieved by a metal-free, base-promoted reaction of pyrrolidine and aromatic aldehydes under microwave irradiation. The rare functionalization of an sp3 C–H bond probably results from an in situ generated azomethine ylide that undergoes cycloaddition with aldehydes.