Issue 30, 2014

Expanding the genetic code for site-specific labelling of tobacco mosaic virus coat protein and building biotin-functionalized virus-like particles

Abstract

A method for site-specific and high yield modification of tobacco mosaic virus coat protein (TMVCP) utilizing a genetic code expanding technology and copper free cycloaddition reaction has been established, and biotin-functionalized virus-like particles were built by the self-assembly of the protein monomers.

Graphical abstract: Expanding the genetic code for site-specific labelling of tobacco mosaic virus coat protein and building biotin-functionalized virus-like particles

Supplementary files

Article information

Article type
Communication
Submitted
01 Dec 2013
Accepted
17 Feb 2014
First published
19 Feb 2014

Chem. Commun., 2014,50, 4007-4009

Author version available

Expanding the genetic code for site-specific labelling of tobacco mosaic virus coat protein and building biotin-functionalized virus-like particles

F. C. Wu, H. Zhang, Q. Zhou, M. Wu, Z. Ballard, Y. Tian, J. Y. Wang, Z. W. Niu and Y. Huang, Chem. Commun., 2014, 50, 4007 DOI: 10.1039/C3CC49137D

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