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Issue 15, 2014
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Synthesis of γ-labeled nucleoside 5′-triphosphates using click chemistry

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Abstract

Real-time enzymatic studies are gaining importance as their chemical and technical instrumentation improves. Here we report the efficient synthesis of γ-alkyne modified triphosphate amidates that are converted into a variety of γ-fluorophore labeled triphosphates by Cu(I) catalyzed alkyne/azide click reactions. The synthesized triphosphates are incorporated into DNA by DNA polymerases.

Graphical abstract: Synthesis of γ-labeled nucleoside 5′-triphosphates using click chemistry

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Supplementary files

Article information


Submitted
22 Nov 2013
Accepted
19 Dec 2013
First published
20 Dec 2013

Chem. Commun., 2014,50, 1861-1863
Article type
Communication
Author version available

Synthesis of γ-labeled nucleoside 5′-triphosphates using click chemistry

S. Serdjukow, F. Kink, B. Steigenberger, M. Tomás-Gamasa and T. Carell, Chem. Commun., 2014, 50, 1861
DOI: 10.1039/C3CC48937J

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