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Issue 15, 2014
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Modular automated solid phase synthesis of dermatan sulfate oligosaccharides

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Abstract

Dermatan sulfates are glycosaminoglycan polysaccharides that serve a multitude of biological roles as part of the extracellular matrix. Orthogonally protected D-galactosamine and L-iduronic acid building blocks and a photo-cleavable linker are instrumental for the automated synthesis of dermatan sulfate oligosaccharides. Conjugation-ready oligosaccharides were obtained in good yield.

Graphical abstract: Modular automated solid phase synthesis of dermatan sulfate oligosaccharides

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Supplementary files

Article information


Submitted
20 Nov 2013
Accepted
24 Dec 2013
First published
03 Jan 2014

Chem. Commun., 2014,50, 1875-1877
Article type
Communication
Author version available

Modular automated solid phase synthesis of dermatan sulfate oligosaccharides

J. Kandasamy, F. Schuhmacher, H. S. Hahm, J. C. Klein and P. H. Seeberger, Chem. Commun., 2014, 50, 1875
DOI: 10.1039/C3CC48860H

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