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Issue 14, 2014
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Ionic liquids provide unique opportunities for oral drug delivery: structure optimization and in vivo evidence of utility

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Abstract

Ionic liquids (ILs) have been exploited to improve the absorption of poorly water-soluble drugs. Custom-made ILs solubilized very high quantities of the poorly water-soluble drugs, danazol and itraconazole, and maintained drug solubilization under simulated gastro-intestinal conditions. A danazol-containing self-emulsifying IL formulation gave rise to 4.3-fold higher exposure than the crystalline drug and prolonged exposure compared with a lipid formulation.

Graphical abstract: Ionic liquids provide unique opportunities for oral drug delivery: structure optimization and in vivo evidence of utility

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Publication details

The article was received on 13 Nov 2013, accepted on 16 Dec 2013 and first published on 17 Dec 2013


Article type: Communication
DOI: 10.1039/C3CC48650H
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Chem. Commun., 2014,50, 1688-1690

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    Ionic liquids provide unique opportunities for oral drug delivery: structure optimization and in vivo evidence of utility

    H. D. Williams, Y. Sahbaz, L. Ford, T. Nguyen, P. J. Scammells and C. J. H. Porter, Chem. Commun., 2014, 50, 1688
    DOI: 10.1039/C3CC48650H

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