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Issue 22, 2014
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Highly selective and controllable synthesis of arylhydroxylamines by the reduction of nitroarenes with an electron-withdrawing group using a new nitroreductase BaNTR1

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Abstract

A new bacterial nitroreductase has been identified and used as a biocatalyst for the controllable reduction of a variety of nitroarenes with an electron-withdrawing group to the corresponding N-arylhydroxylamines under mild reaction conditions with excellent selectivity (>99%). This method therefore represents a green and efficient method for the synthesis of arylhydroxylamines.

Graphical abstract: Highly selective and controllable synthesis of arylhydroxylamines by the reduction of nitroarenes with an electron-withdrawing group using a new nitroreductase BaNTR1

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Publication details

The article was received on 11 Nov 2013, accepted on 23 Jan 2014 and first published on 27 Jan 2014


Article type: Communication
DOI: 10.1039/C3CC48590K
Citation: Chem. Commun., 2014,50, 2861-2864

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    Highly selective and controllable synthesis of arylhydroxylamines by the reduction of nitroarenes with an electron-withdrawing group using a new nitroreductase BaNTR1

    H. Nguyen-Tran, G. Zheng, X. Qian and J. Xu, Chem. Commun., 2014, 50, 2861
    DOI: 10.1039/C3CC48590K

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