We report the optimization of a neglected reaction for the rapid and direct conversion of oxazoles into N-substituted imidazoles. The utility of this microwave-promoted reaction for diversity-oriented synthesis is demonstrated in the preparation of >40 N-substituted imidazoles, including α-imidazolyl esters.
T. Alzieu, J. Lehmann, A. B. Naidu, R. E. Martin and R. Britton, Chem. Commun., 2014, 50, 1867 DOI: 10.1039/C3CC48467J
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