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Issue 15, 2014
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Converting oxazoles into imidazoles: new opportunities for diversity-oriented synthesis

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Abstract

We report the optimization of a neglected reaction for the rapid and direct conversion of oxazoles into N-substituted imidazoles. The utility of this microwave-promoted reaction for diversity-oriented synthesis is demonstrated in the preparation of >40 N-substituted imidazoles, including α-imidazolyl esters.

Graphical abstract: Converting oxazoles into imidazoles: new opportunities for diversity-oriented synthesis

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Publication details

The article was received on 05 Nov 2013, accepted on 20 Dec 2013 and first published on 09 Jan 2014


Article type: Communication
DOI: 10.1039/C3CC48467J
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Chem. Commun., 2014,50, 1867-1870

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    Converting oxazoles into imidazoles: new opportunities for diversity-oriented synthesis

    T. Alzieu, J. Lehmann, A. B. Naidu, R. E. Martin and R. Britton, Chem. Commun., 2014, 50, 1867
    DOI: 10.1039/C3CC48467J

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