Jump to main content
Jump to site search

Issue 15, 2014
Previous Article Next Article

Structural insights into how 5-hydroxymethylation influences transcription factor binding

Author affiliations

Abstract

Transcription factor binding and high resolution crystallographic studies (1.3 Å) of Dickerson–Drew duplexes with cytosine, methylcytosine and hydroxymethylcytosine bases provide evidence that C-5 cytosine modifications could regulate transcription by context dependent effects on DNA transcription factor interactions.

Graphical abstract: Structural insights into how 5-hydroxymethylation influences transcription factor binding

Back to tab navigation

Supplementary files

Article information


Submitted
24 Oct 2013
Accepted
19 Nov 2013
First published
29 Nov 2013

Chem. Commun., 2014,50, 1794-1796
Article type
Communication

Structural insights into how 5-hydroxymethylation influences transcription factor binding

L. Lercher, M. A. McDonough, A. H. El-Sagheer, A. Thalhammer, S. Kriaucionis, T. Brown and C. J. Schofield, Chem. Commun., 2014, 50, 1794
DOI: 10.1039/C3CC48151D

Social activity

Search articles by author

Spotlight

Advertisements