Issue 8, 2014
From the journal:

Chemical Communications

Enzyme-free fluorescent-amplified aptasensors based on target-responsive DNA strand displacement via toehold-mediated click chemical ligation†

Motoi Oishi,*a   Shingo Nakaoa  and  Daiki Katoa  

* Corresponding authors

a Division of Materials Science, Faculty of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8573, Japan
E-mail: oishi@ims.tsukuba.ac.jp
Tel: +81-29-853-5935

Abstract

A new target-responsive DNA strand displacement system via toehold-mediated click chemical ligation was designed and prepared for enzyme-free fluorescent-amplified aptasensors. The aptasensors significantly amplified fluorescent signals in response to targets based on target recycling processes.

Graphical abstract: Enzyme-free fluorescent-amplified aptasensors based on target-responsive DNA strand displacement via toehold-mediated click chemical ligation

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Article information

DOI
https://doi.org/10.1039/C3CC48064J
Article type
Communication
Submitted
21 Oct 2013
Accepted
15 Nov 2013
First published
18 Nov 2013

Chem. Commun., 2014,50, 991-993

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Enzyme-free fluorescent-amplified aptasensors based on target-responsive DNA strand displacement via toehold-mediated click chemical ligation

M. Oishi, S. Nakao and D. Kato, Chem. Commun., 2014, 50, 991 DOI: 10.1039/C3CC48064J

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