High yield and high specific activity synthesis of [18F]fallypride in a batch microfluidic reactor for micro-PET imaging†
Abstract
[18F]fallypride was synthesized in a batch microfluidic chip with a radiochemical yield of 65 ± 6% (n = 7) and an average specific activity of 730 GBq μmol−1 (20 Ci μmol−1) (n = 4). Specific activity was ∼2-fold higher than [18F]fallypride synthesized in a macroscale radiosynthesizer, despite starting with significantly less radioactivity, and thus safer conditions, in the microchip.