Issue 12, 2014
From the journal:

Chemical Communications

A copper-mediated tandem reaction through isocyanide insertion into N–H bonds: efficient access to unsymmetrical tetrasubstituted ureas†

Xiaomei Huang,a   Shuguang Xu,a   Qitao Tan,a   Mingchun Gao,a   Minjie Lia  and  Bin Xu*abc  

* Corresponding authors

a Department of Chemistry, Shanghai University, Shanghai 200444, P. R. China
E-mail: xubin@shu.edu.cn
Fax: +86-21-66132830
Tel: +86-21-66132830

b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. China

c Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, Shanghai 200062, China

Abstract

A copper-mediated multi-component reaction was developed through isocyanide insertion into N–H bonds of less active secondary arylamines. This approach leads to an efficient synthesis of unsymmetrical tetrasubstituted ureas in one pot.

Graphical abstract: A copper-mediated tandem reaction through isocyanide insertion into N–H bonds: efficient access to unsymmetrical tetrasubstituted ureas

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Article information

DOI
https://doi.org/10.1039/C3CC47590E
Article type
Communication
Submitted
03 Oct 2013
Accepted
26 Nov 2013
First published
27 Nov 2013

Chem. Commun., 2014,50, 1465-1468

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A copper-mediated tandem reaction through isocyanide insertion into N–H bonds: efficient access to unsymmetrical tetrasubstituted ureas

X. Huang, S. Xu, Q. Tan, M. Gao, M. Li and B. Xu, Chem. Commun., 2014, 50, 1465 DOI: 10.1039/C3CC47590E

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