Issue 10, 2014
From the journal:

Chemical Communications

Fluoromethylated derivatives of carnitine biosynthesis intermediates – synthesis and applications†

Anna M. Rydzik,a   Ivanhoe K. H. Leung,a   Armin Thalhammer,a   Grazyna T. Kochan,‡b   Timothy D. W. Claridgea  and  Christopher J. Schofield*a  

* Corresponding authors

a Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA, UK
E-mail: christopher.schofield@chem.ox.ac.uk

b Structural Genomics Consortium, University of Oxford, Old Road Campus Roosvelt Drive, Headington OX3 7DQ, UK

Abstract

A convenient method for the synthesis of fluoromethylated carnitine biosynthesis intermediates, i.e. fluorinated derivatives of γ-butyrobetaine and trimethyllysine, is described. The fluoromethylated probes were useful in both in vitro and cell based assays employing 19F NMR and LC-MS analyses.

Graphical abstract: Fluoromethylated derivatives of carnitine biosynthesis intermediates – synthesis and applications

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Article information

DOI
https://doi.org/10.1039/C3CC47581F
Article type
Communication
Submitted
02 Oct 2013
Accepted
20 Nov 2013
First published
21 Nov 2013
This article is Open Access
Creative Commons BY license

Chem. Commun., 2014,50, 1175-1177

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Fluoromethylated derivatives of carnitine biosynthesis intermediates – synthesis and applications

A. M. Rydzik, I. K. H. Leung, A. Thalhammer, G. T. Kochan, T. D. W. Claridge and C. J. Schofield, Chem. Commun., 2014, 50, 1175 DOI: 10.1039/C3CC47581F

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