Amide bond formation via C(sp3)–H bond functionalization and CO insertion

Huizhen Liu; Gabor Laurenczy; Ning Yan; Paul J. Dyson

doi:10.1039/C3CC47015F

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Amide bond formation via C(sp³)–H bond functionalization and CO insertion†‡

Huizhen Liu,^a Gabor Laurenczy,^a Ning Yan^a and Paul J. Dyson*^a

Author affiliations

* Corresponding authors

^a Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland
E-mail: Paul.Dyson@epfl.ch
Fax: +41-21-6939865

Abstract

An efficient method for the synthesis of amides via Pd-catalyzed oxidative carbonylation of C(sp³)–H bonds with CO and amines is described. The route efficiently provides substituted phenyl amides from alkanes.

Download options Please wait...

Supplementary files

Supplementary information PDF (1986K)

Article information

DOI: https://doi.org/10.1039/C3CC47015F
Article type: Communication
Submitted: 13 Sep 2013
Accepted: 30 Oct 2013
First published: 30 Oct 2013
This article is Open Access

Download Citation

Chem. Commun., 2014,50, 341-343

Permissions

Request permissions

Amide bond formation via C(sp³)–H bond functionalization and CO insertion

H. Liu, G. Laurenczy, N. Yan and P. J. Dyson, Chem. Commun., 2014, 50, 341 DOI: 10.1039/C3CC47015F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications