Issue 3, 2014
From the journal:

Chemical Communications

A novel small-molecule binds to the influenza A virus RNA promoter and inhibits viral replication†

Mi-Kyung Lee,ab   Angel Bottini,cd   Meehyein Kim,e   Michael F. Bardaro, Jr.,a   Ziming Zhang,c   Maurizio Pellecchia,*c   Byong-Seok Choi*b  and  Gabriele Varani*af  

* Corresponding authors

a Department of Chemistry, University of Washington, Box 351700, Seattle, WA 98195, USA
E-mail: varani@chem.washington.edu
Fax: +1-206-685-8665
Tel: +1-206-543-7113

b Department of Chemistry, KAIST, Daejeon 305-701, Republic of Korea
E-mail: byongseok.choi@kaist.ac.kr

c Infectious Diseases and Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA
E-mail: mpellecchia@sanfordburnham.org

d Sanford Burnham Graduate School of Biomedical Sciences, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA

e Virus Research and Testing Group, Bio-organic Science Division, KRICT, Daejeon 305-600, Republic of Korea

f Department of Biochemistry, University of Washington, Seattle, WA 98195, USA

Abstract

Through screening by NMR spectroscopy, we discovered a novel scaffold (DPQ: 6,7-dimethoxy-2-(1-piperazinyl)-4-quinazolinamine) that binds specifically to the influenza A virus RNA promoter. The solution structure of the RNA–DPQ complex reported here demonstrates that the internal loop is the binding site of DPQ. The scaffold exhibits antiviral activity against influenza viruses.

Graphical abstract: A novel small-molecule binds to the influenza A virus RNA promoter and inhibits viral replication

About
Cited by
Related
Download options Please wait...

Associated articles

Supplementary files

Article information

DOI
https://doi.org/10.1039/C3CC46973E
Article type
Communication
Submitted
12 Sep 2013
Accepted
29 Oct 2013
First published
29 Oct 2013

Chem. Commun., 2014,50, 368-370

Permissions

Request permissions

A novel small-molecule binds to the influenza A virus RNA promoter and inhibits viral replication

M. Lee, A. Bottini, M. Kim, M. F. Bardaro, Z. Zhang, M. Pellecchia, B. Choi and G. Varani, Chem. Commun., 2014, 50, 368 DOI: 10.1039/C3CC46973E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements