In vivo ratiometric Zn2+ imaging in zebrafish larvae using a new visible light excitable fluorescent sensor

Zhipeng Liu; Changli Zhang; Yuncong Chen; Fang Qian; Yang Bai; Weijiang He; Zijian Guo

doi:10.1039/C3CC46262E

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In vivo ratiometric Zn²⁺ imaging in zebrafish larvae using a new visible light excitable fluorescent sensor†

Zhipeng Liu,‡^ab Changli Zhang,‡^ac Yuncong Chen,^a Fang Qian,^a Yang Bai,^a Weijiang He*^a and Zijian Guo*^a

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* Corresponding authors

^a State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China
E-mail: heweij69@nju.edu.cn, zguo@nju.edu.cn
Fax: +86 25 83314502
Tel: +86 25 83597066

^b Department of chemistry, Liaocheng Unviersity, Liaocheng, P. R. China

^c Department of chemistry, Nanjing Xiaozhuang College, Nanjing, P. R. China

Abstract

A visible light excitable ratiometric Zn²⁺ sensor was developed by integrating a Zn²⁺ chelator as the ICT donor of the fluorophore sulfamoylbenzoxadiazole, which displays the Zn²⁺-induced hypsochromic emission shift (40 nm) and favors the in vivo ratiometric Zn²⁺ imaging in zebrafish larvae.

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Article information

DOI: https://doi.org/10.1039/C3CC46262E
Article type: Communication
Submitted: 15 Aug 2013
Accepted: 25 Nov 2013
First published: 26 Nov 2013

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Chem. Commun., 2014,50, 1253-1255

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In vivo ratiometric Zn²⁺ imaging in zebrafish larvae using a new visible light excitable fluorescent sensor

Z. Liu, C. Zhang, Y. Chen, F. Qian, Y. Bai, W. He and Z. Guo, Chem. Commun., 2014, 50, 1253 DOI: 10.1039/C3CC46262E

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Chemical Communications