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Issue 2, 2014
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Conversion of nitrite to nitric oxide at zinc via S-nitrosothiols

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Abstract

Nitrite is an important reservoir of nitric oxide activity in the plasma and cells. Using a biomimetic model, we demonstrate the conversion of zinc-bound nitrite in the tris(pyrazolyl)borate complex iPr2TpZn(NO2) to the corresponding S-nitrosothiol RSNO and zinc thiolate iPr2TpZn–SR via reaction with thiols H–SR. Decomposition of the S-nitrosothiol formed releases nitric oxide gas.

Graphical abstract: Conversion of nitrite to nitric oxide at zinc via S-nitrosothiols

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Article information


Submitted
09 Aug 2013
Accepted
27 Oct 2013
First published
28 Oct 2013

Chem. Commun., 2014,50, 168-170
Article type
Communication

Conversion of nitrite to nitric oxide at zinc via S-nitrosothiols

A. J. P. Cardenas, R. Abelman and T. H. Warren, Chem. Commun., 2014, 50, 168
DOI: 10.1039/C3CC46102E

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