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Issue 4, 2014
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β-Sultams exhibit discrete binding preferences for diverse bacterial enzymes with nucleophilic residues

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Abstract

β-Sultams are potent electrophiles that modify nucleophilic residues in selected enzyme active sites. We here identify and characterize some of the specific bacterial targets and show a unique inhibition of the azoreductase family.

Graphical abstract: β-Sultams exhibit discrete binding preferences for diverse bacterial enzymes with nucleophilic residues

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Supplementary files

Article information


Submitted
06 Aug 2013
Accepted
25 Oct 2013
First published
30 Oct 2013

Chem. Commun., 2014,50, 427-429
Article type
Communication

β-Sultams exhibit discrete binding preferences for diverse bacterial enzymes with nucleophilic residues

R. Kolb, N. C. Bach and S. A. Sieber, Chem. Commun., 2014, 50, 427
DOI: 10.1039/C3CC46002A

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