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Issue 2, 2014
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In situ-forming robust chitosan-poly(ethylene glycol) hydrogels prepared by copper-free azide–alkyne click reaction for tissue engineering

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Abstract

A water-soluble azide-functionalised chitosan was crosslinked with propiolic acid ester-functional poly(ethylene glycol) using copper-free click chemistry. The resultant hydrogel materials were formed within 5–60 min at 37 °C and resulted in mechanically robust materials with tuneable properties such as swelling, mechanical strength and degradation. Importantly, the hydrogels supported mesenchymal stem cell attachment and proliferation and were also non-toxic to encapsulated cells. As such these studies indicate that the hydrogels have potential to be used as injectable biomaterials for tissue engineering.

Graphical abstract: In situ-forming robust chitosan-poly(ethylene glycol) hydrogels prepared by copper-free azide–alkyne click reaction for tissue engineering

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Publication details

The article was received on 26 Jun 2013, accepted on 20 Sep 2013 and first published on 04 Oct 2013


Article type: Paper
DOI: 10.1039/C3BM60159E
Citation: Biomater. Sci., 2014,2, 167-175
  • Open access: Creative Commons BY license
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    In situ-forming robust chitosan-poly(ethylene glycol) hydrogels prepared by copper-free azide–alkyne click reaction for tissue engineering

    V. X. Truong, M. P. Ablett, H. T. J. Gilbert, J. Bowen, S. M. Richardson, J. A. Hoyland and A. P. Dove, Biomater. Sci., 2014, 2, 167
    DOI: 10.1039/C3BM60159E

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