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Issue 20, 2014
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A simple microfluidic electrochemical HPLC detector for quantifying Fenton reactivity from welding fumes

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Abstract

Development and characterization of a simple microfluidic electrochemical flow cell that can be coupled with HPLC to enable dual absorbance/electrochemical detection is described. Coupling absorbance and electrochemical detection increases the information that can be gathered from a single injection, but a second (typically expensive) detection system is required. Here, an inexpensive, customizable microfluidic electrochemical detector is coupled in series with a commercial HPLC/UV system. The microfluidic device is made from poly(dimethylsiloxane) and contains carbon paste electrodes. To demonstrate the utility of this dual-detection system, the reaction products of the radical scavenging agent salicylic acid and hydroxyl radical generated by Fenton chemistry were analyzed. The dual-detection system was used to quantify 2,5-dihydroxybenzoic acid, 2,3-dihydroxybenzoic acid, and catechol produced by the addition of H2O2 to filter samples of welding fumes. Measurement recovery was high, with percent recoveries between 97–102%, 92–103%, and 95–103% for 2,5-dihydroxybenzoic acid, 2,3-dihydroxybenzoic acid, and catechol, respectively, for control samples. The methods described in this work are simple, reliable, and can inexpensively couple electrochemical detection to HPLC-UV systems.

Graphical abstract: A simple microfluidic electrochemical HPLC detector for quantifying Fenton reactivity from welding fumes

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Article information


Submitted
27 Jun 2014
Accepted
19 Aug 2014
First published
20 Aug 2014

Anal. Methods, 2014,6, 8180-8186
Article type
Paper
Author version available

A simple microfluidic electrochemical HPLC detector for quantifying Fenton reactivity from welding fumes

T. Pluangklang, J. B. Wydallis, D. M. Cate, D. Nacapricha and C. S. Henry, Anal. Methods, 2014, 6, 8180
DOI: 10.1039/C4AY01534G

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