Sensitive determination of urapidil at an electrochemically pretreated glassy carbon electrode by linear sweep voltammetry

Abstract

A very simple and sensitive voltammetric method for the determination of urapidil was proposed by electrochemical pretreatment using a glassy carbon electrode as the voltammetric sensor (EPGCE). The EPGCE was obtained by cycling the electrode between a potential of −1.5 and 2.5 V, for five cycles in 0.1 M pH 7.0 PBS. Compared with the bare GCE, the EPGCE had an excellent response towards the oxidation of urapidil. Under the optimal conditions, the selective detection of urapidil in a linear concentration range of 2.0 × 10⁻⁸ to 5.0 × 10⁻⁶ mol L⁻¹ was obtained with a determination limit of 2.0 × 10⁻⁸ mol L⁻¹. At the same time, the EPGCE was also applied to the detection of urapidil content in urapidil sustained-release tablets and urine samples with satisfactory results.