Interaction of organic compounds and boron clusters with new silica matrices containing the phosphatidylcholine headgroup

Abstract

Silica chromatography matrices containing the phosphatidylcholine headgroup have been prepared in order to allow the study of solutes interacting with the surface of lipid membranes. The headgroups were attached to the silica gel with two different methods, and with and without a hexyl spacer. Different organic compounds and dodecaborate clusters were investigated on these matrices, and compared to phosphatidylcholine liposomes covalently immobilized on silica gel. The correlation of elution when comparing the matrices pairwise was in general good for organic compounds, and excellent for dodecaborate clusters. Brominated and iodinated dodecaborate could not be eluted from phosphatidylcholine liposomes, while their retention on the other matrices was not exceptionally strong. For applying the linear free energy relation formalism to boron clusters, further descriptors appear to be required.