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Issue 7, 2014
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Exploration of a β-cyclodextrin clicked chiral stationary phase in high-performance liquid chromatography

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Abstract

The baseline enantioseparation of 19 racemic drugs including ondansetron, citalopram, galanthamine base, pregabalin, timolol, atenolol, tropicamide, ephedrine hydrochloride, flavanoids and aryl alcohols has been successfully achieved with a cyclodextrin clicked chiral stationary phase in high performance liquid chromatography. The best separation results were presented under optimized conditions. The effect of organic modifiers including methanol and acetonitrile on the enantioseparation of racemates was also studied. Chiral resolutions of 4.19 and 4.42 were achieved for citalopram and tropicamide, respectively.

Graphical abstract: Exploration of a β-cyclodextrin clicked chiral stationary phase in high-performance liquid chromatography

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Article information


Submitted
10 Dec 2013
Accepted
20 Jan 2014
First published
21 Jan 2014

Anal. Methods, 2014,6, 2034-2037
Article type
Communication
Author version available

Exploration of a β-cyclodextrin clicked chiral stationary phase in high-performance liquid chromatography

S. Zhang, H. Wang, J. Tang, W. Wang and W. Tang, Anal. Methods, 2014, 6, 2034
DOI: 10.1039/C3AY42193G

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