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Issue 2, 2014
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Double shell CdTe/CdS/ZnS quantum dots as a fluorescence probe for quetiapine determination in fumarate quetiapine tablets

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Abstract

A simple, sensitive and convenient method based on the fluorescence quenching of double shell CdTe/CdS/ZnS quantum dots (QDs) by quetiapine was proposed. CdTe/CdS/ZnS QDs were synthesized by a one-pot capping method in aqueous solution and characterized by absorption spectroscopy, fluorescence spectroscopy, X-ray photoelectron spectroscopy and transmission electron microscopy. Under optimal conditions, the calibration plot of F0/F versus the concentration of quetiapine was linear in the range of 5–100 μM with a correlation coefficient of 0.9958. The limit of detection was 0.8 μM. The concentration of quetiapine in quetiapine fumarate tablets was determined by the proposed method and the results agreed with the claimed values. The possible fluorescence quenching mechanism was discussed.

Graphical abstract: Double shell CdTe/CdS/ZnS quantum dots as a fluorescence probe for quetiapine determination in fumarate quetiapine tablets

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Article information


Submitted
12 Sep 2013
Accepted
06 Nov 2013
First published
06 Nov 2013

Anal. Methods, 2014,6, 482-489
Article type
Paper

Double shell CdTe/CdS/ZnS quantum dots as a fluorescence probe for quetiapine determination in fumarate quetiapine tablets

F. Wei, Y. Lin, Y. Wu, X. Sun, L. Liu, P. Zhou and Q. Hu, Anal. Methods, 2014, 6, 482
DOI: 10.1039/C3AY41580E

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