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Issue 1, 2014
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Monitoring the mineralisation of bone nodules in vitro by space- and time-resolved Raman micro-spectroscopy

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Abstract

Raman microscopy was used as a label-free method to study the mineralisation of bone nodules formed by mesenchymal stem cells cultured in osteogenic medium in vitro. Monitoring individual bone nodules over 28 days revealed temporal and spatial changes in the crystalline phase of the hydroxyapatite components of the nodules.

Graphical abstract: Monitoring the mineralisation of bone nodules in vitro by space- and time-resolved Raman micro-spectroscopy

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Publication details

The article was received on 09 Sep 2013, accepted on 15 Oct 2013 and first published on 16 Oct 2013


Article type: Communication
DOI: 10.1039/C3AN01716H
Citation: Analyst, 2014,139, 55-58
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    Monitoring the mineralisation of bone nodules in vitro by space- and time-resolved Raman micro-spectroscopy

    A. Ghita, F. C. Pascut, V. Sottile and I. Notingher, Analyst, 2014, 139, 55
    DOI: 10.1039/C3AN01716H

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