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Issue 22, 2014
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Surface-assisted laser desorption/ionization mass spectrometry using ordered silicon nanopillar arrays

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Abstract

Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) is ideally suited for the high-throughput analysis of small molecules in bodily fluids (e.g. saliva, urine, and blood plasma). A key application for this technique is the testing of drug consumption in the context of workplace, roadside, athlete sports and anti-addictive drug compliance. Here, we show that vertically-aligned ordered silicon nanopillar (SiNP) arrays fabricated using nanosphere lithography followed by metal-assisted chemical etching (MACE) are suitable substrates for the SALDI-MS detection of methadone and small peptides. Porosity, length and diameter are fabrication parameters that we have explored here in order to optimize analytical performance. We demonstrate the quantitative analysis of methadone in MilliQ water down to 32 ng mL−1. Finally, the capability of SiNP arrays to facilitate the detection of methadone in clinical samples is also demonstrated.

Graphical abstract: Surface-assisted laser desorption/ionization mass spectrometry using ordered silicon nanopillar arrays

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Supplementary files

Article information


Submitted
28 Jul 2014
Accepted
22 Sep 2014
First published
22 Sep 2014

This article is Open Access

Analyst, 2014,139, 5999-6009
Article type
Paper

Surface-assisted laser desorption/ionization mass spectrometry using ordered silicon nanopillar arrays

H. Z. Alhmoud, T. M. Guinan, R. Elnathan, H. Kobus and N. H. Voelcker, Analyst, 2014, 139, 5999
DOI: 10.1039/C4AN01391C

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    [Original citation] - Published by The Royal Society of Chemistry.

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