A fluorescent probe with restricted intramolecular rotation-induced emission for label-free detection of mercury ions

Shengliang Li; Hua Deng; Weipeng Cao; Chunqiu Zhang; Shubin Jin; Xiangdong Xue; Jinchao Zhang; Feng Li; Guozhang Zou; Xing-Jie Liang

doi:10.1039/C4AN00460D

A fluorescent probe with restricted intramolecular rotation-induced emission for label-free detection of mercury ions†

Shengliang Li,‡^ab Hua Deng,‡^a Weipeng Cao,^a Chunqiu Zhang,^a Shubin Jin,^a Xiangdong Xue,^a Jinchao Zhang,^c Feng Li,^b Guozhang Zou*^a and Xing-Jie Liang*^a

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^a Laboratory of Nanomedicine and Nanosafety, Division of Nanomedicine and Nanobiology, National Center for Nanoscience and Technology of China, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences, Beijing, China
E-mail: zougz@nanoctr.cn, liangxj@nanoctr.cn

^b Department of Neurobiology and Anatomy, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China

^c College of Chemistry & Environmental Science, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding, China

Abstract

Formation of T–Hg²⁺–T complexes changes the configuration of a single-stranded DNA, leading to enhanced fluorescence of an anchored cyanine-based probe that displays restricted intramolecular rotation (RIR)-induced emission. This label-free system can be used as a sensor for mercury ions with a detection limit of 4 nM.

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A fluorescent probe with restricted intramolecular rotation-induced emission for label-free detection of mercury ions†

Abstract

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A fluorescent probe with restricted intramolecular rotation-induced emission for label-free detection of mercury ions

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