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Issue 9, 2014
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Rational selection of substrates to improve color intensity and uniformity on microfluidic paper-based analytical devices

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Abstract

A systematic investigation was conducted to study the effect of paper type on the analytical performance of a series of microfluidic paper-based analytical devices (μPADs) fabricated using a CO2 laser engraver. Samples included three different grades of Whatman chromatography paper, and three grades of Whatman filter paper. According to the data collected and the characterization performed, different papers offer a wide range of flow rate, thickness, and pore size. After optimizing the channel widths on the μPAD, the focus of this study was directed towards the color intensity and color uniformity formed during a colorimetric enzymatic reaction. According to the results herein described, the type of paper and the volume of reagents dispensed in each detection zone can determine the color intensity and uniformity. Therefore, the objective of this communication is to provide rational guidelines for the selection of paper substrates for the fabrication of μPADs.

Graphical abstract: Rational selection of substrates to improve color intensity and uniformity on microfluidic paper-based analytical devices

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Publication details

The article was received on 30 Jan 2014, accepted on 28 Feb 2014 and first published on 03 Mar 2014


Article type: Communication
DOI: 10.1039/C4AN00230J
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Analyst, 2014,139, 2127-2132

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    Rational selection of substrates to improve color intensity and uniformity on microfluidic paper-based analytical devices

    E. Evans, E. F. M. Gabriel, W. K. T. Coltro and C. D. Garcia, Analyst, 2014, 139, 2127
    DOI: 10.1039/C4AN00230J

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