Jump to main content
Jump to site search

Issue 32, 2013
Previous Article Next Article

Biodegradable chitosan/alginate BSA-gel-capsules for pH-controlled loading and release of doxorubicin and treatment of pulmonary melanoma

Author affiliations

Abstract

We engineered advanced biodegradable chitosan–alginate BSA-gel-capsules and demonstrated their applicability for the treatment of lung diseases. The pH-controlled loading and release of doxorubicin (DOX) was demonstrated. After treatment with DOX-loaded chitosan–alginate BSA-gel-capsules, effective cytotoxicity against B16F10 cells in vitro and higher efficacy of the pulmonary melanoma in vivo were revealed. In particular, the real-time biodistribution of DOX from DOX-loaded capsules was investigated for the first time, indicating the metabolism of capsules from the lung. These engineered capsules present new opportunities en route to the development of polyelectrolyte microcapsules for drug delivery.

Graphical abstract: Biodegradable chitosan/alginate BSA-gel-capsules for pH-controlled loading and release of doxorubicin and treatment of pulmonary melanoma

Back to tab navigation

Supplementary files

Publication details

The article was received on 10 Mar 2013, accepted on 17 May 2013 and first published on 20 May 2013


Article type: Paper
DOI: 10.1039/C3TB20330A
Citation: J. Mater. Chem. B, 2013,1, 3906-3917
  •   Request permissions

    Biodegradable chitosan/alginate BSA-gel-capsules for pH-controlled loading and release of doxorubicin and treatment of pulmonary melanoma

    H. Shen, H. Shi, M. Xie, K. Ma, B. Li, S. Shen, X. Wang and Y. Jin, J. Mater. Chem. B, 2013, 1, 3906
    DOI: 10.1039/C3TB20330A

Search articles by author

Spotlight

Advertisements