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Issue 42, 2013
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Hybrid polymersomes: facile manipulation of vesicular surfaces for enhancing cellular interaction

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Abstract

Facile surface modification via the blending of lipids and block-co-polymers to assemble hybrid vesicles was investigated for improving cellular interaction and antigen delivery of poly(ethylene glycol) (PEG)-based polymersomes. Cationic lipids (DOTAP) incorporated into PEG-b-PBD polymersomes increased the binding and uptake of vesicles by antigen-presenting cells, while preserving the stability and biocompatibility of PEG-based polymersomes, resulting in the enhanced cellular delivery of a loaded lipid antigen sulfatide.

Graphical abstract: Hybrid polymersomes: facile manipulation of vesicular surfaces for enhancing cellular interaction

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Article information


Submitted
07 Aug 2013
Accepted
10 Sep 2013
First published
11 Sep 2013

J. Mater. Chem. B, 2013,1, 5751-5755
Article type
Communication

Hybrid polymersomes: facile manipulation of vesicular surfaces for enhancing cellular interaction

X. Su, S. K. Mohamed Moinuddeen, L. Mori and M. Nallani, J. Mater. Chem. B, 2013, 1, 5751
DOI: 10.1039/C3TB21111H

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