Issue 11, 2013

Facile aqueous-phase synthesis of multi-responsive nanogels based on polyetheramines and bisepoxide

Abstract

A new strategy for the preparation of nanogels from commercially available monomers of bisepoxide and aliphatic polyetheramine has been developed. The nanogels are generated in a one-pot process through aggregation polymerization of an in situ formed thermal sensitive intermediate polymer in an additive-free and catalyst-free aqueous environment. Such a facile process allows easy size tuning of the gel particles from the nanometer to the micron scale, simply by adjusting the reactant concentration. The obtained nanogels demonstrated responsiveness to multiple biologically relevant stimuli, including temperature, pH, and oxidation. Nile red was encapsulated in the nanogels as a model hydrophobic drug. In vitro drug release studies showed stimuli-triggered release from the nanogels, suggesting the potential for controlled drug delivery.

Graphical abstract: Facile aqueous-phase synthesis of multi-responsive nanogels based on polyetheramines and bisepoxide

Supplementary files

Article information

Article type
Paper
Submitted
05 Dec 2012
Accepted
25 Jan 2013
First published
05 Feb 2013

J. Mater. Chem. B, 2013,1, 1628-1634

Facile aqueous-phase synthesis of multi-responsive nanogels based on polyetheramines and bisepoxide

S. Tang, Z. Shi, Y. Cao and W. He, J. Mater. Chem. B, 2013, 1, 1628 DOI: 10.1039/C3TB00492A

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