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Issue 8, 2013
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Gastric-floating microcapsules provide controlled and sustained release of multiple cardiovascular drugs

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Abstract

Floating polymeric microcapsules that simultaneously entrap multiple drugs were prepared using a solid/water/oil/water emulsion solvent evaporation method, based on harnessing interfacial phenomena and manipulation of the solvent removal process. The fabricated microcapsules exhibited excellent buoyancy in simulated gastric fluid and provided controlled and sustained release of multiple drugs for up to 24 h, thus revealing their potential as a rate-controlled oral drug delivery system.

Graphical abstract: Gastric-floating microcapsules provide controlled and sustained release of multiple cardiovascular drugs

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Publication details

The article was received on 06 Dec 2012, accepted on 03 Jan 2013 and first published on 08 Jan 2013


Article type: Communication
DOI: 10.1039/C2TB00495J
Citation: J. Mater. Chem. B, 2013,1, 1090-1095
  • Open access: Creative Commons BY-NC license
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    Gastric-floating microcapsules provide controlled and sustained release of multiple cardiovascular drugs

    W. L. Lee, P. Wee, C. Nugraha and S. C. J. Loo, J. Mater. Chem. B, 2013, 1, 1090
    DOI: 10.1039/C2TB00495J

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