Issue 9, 2013

PEGylated denatured bovine serum albumin modified water-soluble inorganic nanocrystals as multifunctional drug delivery platforms

Abstract

A novel approach of using denatured bovine serum albumin (dBSA) to modify hydrophobic nanocrystals is reported. The dBSA layer outside of nanocrystals can adsorb water insoluble drugs excellently via hydrophobic interactions. Further PEGylation of the engineered nanocrystals greatly improves their aqueous stability. PEGylated dBSA modified upconversion nanoparticles, as a model for construction of integrating imaging and drug delivery platform, were also studied. The results demonstrated the modified upconversion nanoparticles not only maintain their unique up-conversion luminescence characters but also exhibit higher drug loading ability. Thus, such novel PEGylated dBSA modification approach expands the range of biological applications of inorganic nanocrystals.

Graphical abstract: PEGylated denatured bovine serum albumin modified water-soluble inorganic nanocrystals as multifunctional drug delivery platforms

Supplementary files

Article information

Article type
Paper
Submitted
07 Nov 2012
Accepted
07 Jan 2013
First published
08 Jan 2013

J. Mater. Chem. B, 2013,1, 1289-1295

PEGylated denatured bovine serum albumin modified water-soluble inorganic nanocrystals as multifunctional drug delivery platforms

L. Zhang, Z. Lu, Y. Bai, T. Wang, Z. Wang, J. Chen, Y. Ding, F. Yang, Z. Xiao, S. Ju, J. Zhu and N. He, J. Mater. Chem. B, 2013, 1, 1289 DOI: 10.1039/C2TB00380E

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