Issue 26, 2013
From the journal:

Soft Matter

The effect of pH on the self-assembly of a collagen derived peptide amphiphile†

Ashkan Dehsorkhi,a   Valeria Castelletto,a   Ian W. Hamley,*a   Jozef Adamcikb  and  Raffaele Mezzenga*b  

* Corresponding authors

a Dept of Chemistry, University of Reading, Whiteknights Reading RG6 6AD, UK
E-mail: I.W.Hamley@reading.ac.uk

b Food & Soft Materials Science, ETH Zürich, Schmelzbergstrasse 9, 8092 Zürich, Switzerland
E-mail: raffaele.mezzenga@hest.ethz.ch

Abstract

Transitions in nanostructure driven by pH are observed for a self-assembling peptide amphiphile (PA) with a cationic pentapeptide headgroup. At pH 3, the PA forms flat tape-like structures, while at pH 4 the PA assembles into twisted right handed structures. These twisted structures transform again to flat tape-like structures at pH 7. In complete contrast, spherical micelles are observed at pH 2. These changes in response to pH may be relevant to biological and pharmaceutical applications of this PA in skincare.

Graphical abstract: The effect of pH on the self-assembly of a collagen derived peptide amphiphile

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Article information

DOI
https://doi.org/10.1039/C3SM51029H
Article type
Communication
Submitted
15 Apr 2013
Accepted
22 May 2013
First published
23 May 2013
This article is Open Access
Creative Commons BY license

Soft Matter, 2013,9, 6033-6036

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The effect of pH on the self-assembly of a collagen derived peptide amphiphile

A. Dehsorkhi, V. Castelletto, I. W. Hamley, J. Adamcik and R. Mezzenga, Soft Matter, 2013, 9, 6033 DOI: 10.1039/C3SM51029H

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