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Issue 14, 2013
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A continuum model of epithelial spreading

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We propose a continuum model of unconstrained epithelial spreading. The tissue is described as a polarizable and chemo-mechanically interacting layer with neo-Hookean elasticity. Our model reproduces the spontaneous formation of finger-like protrusions commonly observed in experiment. Statistics of the velocity orientation obtained from numerical simulations show a strong alignment within the fingers, as opposed to an isotropic distribution in the bulk. The results faithfully reproduce the relatively faster advance of cells close to the leading edge of the tissue, as well as experimentally observed spatial velocity correlations and stress accumulation within the tissue.

Graphical abstract: A continuum model of epithelial spreading

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The article was received on 23 Aug 2012, accepted on 29 Jan 2013 and first published on 18 Feb 2013

Article type: Paper
DOI: 10.1039/C3SM26955H
Citation: Soft Matter, 2013,9, 3727-3734

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    A continuum model of epithelial spreading

    M. H. Köpf and L. M. Pismen, Soft Matter, 2013, 9, 3727
    DOI: 10.1039/C3SM26955H

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