Issue 11, 2013

Morphological transition of self-assembled architectures from PEG-based ether-anhydride terpolymers

Abstract

Biodegradable micelles were fabricated by self-assembly in the aqueous solution of PEG-based ether-anhydride terpolymer consisting of poly(ethylene glycol) (PEG), 1,3-bis(p-carboxyphenoxy) propane (CPP) and sebacic acid (SA). Morphological transition of the micelles was investigated in terms of PEG chain length, hydrophilic–hydrophobic segment ratio, polymer concentration and environmental temperature. The effect of micellar shape on drug loading capacity and cytotoxicity was evaluated. The cellular uptake efficiency was characterized qualitatively with the human hepatoblastoma cell lines (HepG2) and fibroblast normal cells by fluorescence microscopy. Primary in vivo biodistribution of the drug-loaded micelles with diverse morphologies in tumor and normal tissues was also assessed using 4T1 bearing mice. The results show that terpolymer micelles with rod-like shape possess better biocompatibility and the in vivo biodistribution is dependent on micellar shape. Therefore, these polymer micelles have great potential as a novel drug vehicle in nanomedicine.

Graphical abstract: Morphological transition of self-assembled architectures from PEG-based ether-anhydride terpolymers

Article information

Article type
Paper
Submitted
20 Sep 2012
Accepted
20 Nov 2012
First published
22 Jan 2013

Soft Matter, 2013,9, 3021-3031

Morphological transition of self-assembled architectures from PEG-based ether-anhydride terpolymers

T. Chen, X. Guo, A. Zhao, J. Wang, C. Shi and S. Zhou, Soft Matter, 2013, 9, 3021 DOI: 10.1039/C2SM27173G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements